Systemic inflammation is a potent prothrombotic stimulus. Inflammatory mechanisms
upregulate procoagulant factors, downregulate natural anticoagulants and inhibit fibrinolytic
activity. In addition to modulating plasma coagulation mechanisms, inflammatory mediators
appear to increase platelet reactivity. In vivo, however, natural anticoagulants not only
prevent thrombosis, but they also dampen inflammatory activity. Some insights into the
evolution and linkages between inflammatory mechanisms and the coagulation …