[HTML][HTML] β-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6
E Galliera, VR Jala, JO Trent, R Bonecchi… - Journal of Biological …, 2004 - ASBMB
Seven transmembrane receptors mediate diverse physiological responses including
hormone action, olfaction, neurotransmission, and chemotaxis. Human D6 is a non-
signaling seven-transmembrane receptor expressed on lymphatic endothelium interacting
with most inflammatory CC-chemokines resulting in their rapid internalization. Here, we
demonstrate that this scavenging activity is mediated by continuous internalization and
constant surface expression of the receptor, a process involving the clathrin-coated pit …
hormone action, olfaction, neurotransmission, and chemotaxis. Human D6 is a non-
signaling seven-transmembrane receptor expressed on lymphatic endothelium interacting
with most inflammatory CC-chemokines resulting in their rapid internalization. Here, we
demonstrate that this scavenging activity is mediated by continuous internalization and
constant surface expression of the receptor, a process involving the clathrin-coated pit …