Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

A Mantovani, P Allavena, S Sozzani, A Vecchi… - Seminars in cancer …, 2004 - Elsevier
A Mantovani, P Allavena, S Sozzani, A Vecchi, M Locati, A Sica
Seminars in cancer biology, 2004Elsevier
Leukocytes, and macrophages in particular, are an important component of the stroma of
neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized
M2 population and are a key component of inflammatory circuits which promote tumor
growth and progression. Chemokines play a key role in the recruitment and positioning of
TAM and dendritic cells in tumors and contribute to shaping their functional properties.
Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of …
Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.
Elsevier