[HTML][HTML] Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia
JP Davies, C Scott, K Oishi, A Liapis… - Journal of Biological …, 2005 - ASBMB
NPC1L1, a recently identified relative of Niemann-Pick C1, was characterized to determine
its subcellular location and potential function (s). NPC1L1 was highly expressed in HepG2
cells and localized in a subcellular vesicular compartment rich in the small GTPase Rab5.
mRNA expression profiling revealed significant differences between mouse and man with
highest expression found in human liver and significant expression in the small intestine. In
contrast, liver expression in mouse was extremely low with mouse small intestine exhibiting …
its subcellular location and potential function (s). NPC1L1 was highly expressed in HepG2
cells and localized in a subcellular vesicular compartment rich in the small GTPase Rab5.
mRNA expression profiling revealed significant differences between mouse and man with
highest expression found in human liver and significant expression in the small intestine. In
contrast, liver expression in mouse was extremely low with mouse small intestine exhibiting …