Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice
Background/Aim: Mutations in genes encoding the ATP-binding cassette (ABC)-transporters
ABCG5 and ABCG8 underlie sitosterolemia, which is characterized by elevated plasma
levels of phytosterols due to increased intestinal absorption and impaired biliary secretion of
sterols. The aim of our study was to correlate the expression levels of Abcg5 and Abcg8 to
biliary cholesterol secretion in various (genetically-modified) mouse models. Methods: Bile
was collected from genetically-modified mice fed a chow diet, or from mice fed either a chow …
ABCG5 and ABCG8 underlie sitosterolemia, which is characterized by elevated plasma
levels of phytosterols due to increased intestinal absorption and impaired biliary secretion of
sterols. The aim of our study was to correlate the expression levels of Abcg5 and Abcg8 to
biliary cholesterol secretion in various (genetically-modified) mouse models. Methods: Bile
was collected from genetically-modified mice fed a chow diet, or from mice fed either a chow …