[HTML][HTML] Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake
L Yu, S Bharadwaj, JM Brown, Y Ma, W Du… - Journal of Biological …, 2006 - ASBMB
Although NPC1L1 is required for intestinal cholesterol absorption, data demonstrating
mechanisms by which this protein facilitates the process are few. In this study, a hepatoma
cell line stably expressing human NPC1L1 was established, and cholesterol uptake was
studied. A relationship between NPC1L1 intracellular trafficking and cholesterol uptake was
apparent. At steady state, NPC1L1 proteins localized predominantly to the transferrin-
positive endocytic recycling compartment, where free cholesterol also accumulated as …
mechanisms by which this protein facilitates the process are few. In this study, a hepatoma
cell line stably expressing human NPC1L1 was established, and cholesterol uptake was
studied. A relationship between NPC1L1 intracellular trafficking and cholesterol uptake was
apparent. At steady state, NPC1L1 proteins localized predominantly to the transferrin-
positive endocytic recycling compartment, where free cholesterol also accumulated as …