[HTML][HTML] Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin …

YH Shen, L Zhang, Y Gan, X Wang, J Wang… - Journal of Biological …, 2006 - ASBMB
The key feature of metabolic syndrome, a cluster of metabolic and cardiovascular disorders,
is systemic insulin resistance, which is associated with dysregulated endothelial nitric-oxide
synthase (eNOS). Stress signaling induced by inflammation can inhibit insulin signaling.
However, molecular mechanisms for the cross-talk between stress signaling and insulin
resistance are only partially understood. Resistin, an adipokine/cytokine, is involved in
inflammatory processes that could lead to insulin resistance status and vascular diseases. In …