Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression
O Boss, S Samec, A Paoloni-Giacobino… - FEBS …, 1997 - Wiley Online Library
O Boss, S Samec, A Paoloni-Giacobino, C Rossier, A Dulloo, J Seydoux, P Muzzin…
FEBS letters, 1997•Wiley Online LibraryBrown adipose tissue (BAT) and skeletal muscle are important sites of nonshivering
thermogenesis. The uncoupling protein‐1 (UCP1) is the main effector of nonshivering
thermogenesis in BAT and the recently described ubiquitous UCP2 [1] has been implicated
in energy balance. In an attempt to better understand the biochemical events underlying
nonshivering thermogenesis in muscle, we screened a human skeletal muscle cDNA library
and isolated three clones: UCP2, UCP3L and UCP3S. The novel UCP3 was 57% and 73 …
thermogenesis. The uncoupling protein‐1 (UCP1) is the main effector of nonshivering
thermogenesis in BAT and the recently described ubiquitous UCP2 [1] has been implicated
in energy balance. In an attempt to better understand the biochemical events underlying
nonshivering thermogenesis in muscle, we screened a human skeletal muscle cDNA library
and isolated three clones: UCP2, UCP3L and UCP3S. The novel UCP3 was 57% and 73 …
Brown adipose tissue (BAT) and skeletal muscle are important sites of nonshivering thermogenesis. The uncoupling protein‐1 (UCP1) is the main effector of nonshivering thermogenesis in BAT and the recently described ubiquitous UCP2 [1]has been implicated in energy balance. In an attempt to better understand the biochemical events underlying nonshivering thermogenesis in muscle, we screened a human skeletal muscle cDNA library and isolated three clones: UCP2, UCP3L and UCP3S. The novel UCP3 was 57% and 73% identical to human UCP1 and UCP2, respectively, highly skeletal muscle‐specific and its expression was unaffected by cold acclimation. This new member of the UCP family is a candidate protein for the modulation of the respiratory control in skeletal muscle.
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