[HTML][HTML] MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
MicroRNAs are small noncoding RNA molecules that control expression of target genes. Our
previous studies show that mir-21 is overexpressed in tumor tissues compared with the
matched normal tissues. Moreover, suppression of mir-21 by antisense oligonucleotides
inhibits tumor cell growth both in vitro and in vivo. However, it remains largely unclear as to
how mir-21 affects tumor growth, because our understanding of mir-21 targets is limited. In
this study, we performed two-dimensional differentiation in-gel electrophoresis of tumors …
previous studies show that mir-21 is overexpressed in tumor tissues compared with the
matched normal tissues. Moreover, suppression of mir-21 by antisense oligonucleotides
inhibits tumor cell growth both in vitro and in vivo. However, it remains largely unclear as to
how mir-21 affects tumor growth, because our understanding of mir-21 targets is limited. In
this study, we performed two-dimensional differentiation in-gel electrophoresis of tumors …