Histologic characterization of acute spinal cord injury treated with intravenous methylprednisolone
A Merola, MF O'Brien, BA Castro… - … of orthopaedic trauma, 2002 - journals.lww.com
A Merola, MF O'Brien, BA Castro, DAB Smith, JM Eule, TG Lowe, AP Dwyer, TR Haher…
Journal of orthopaedic trauma, 2002•journals.lww.comObjective Many substances have been investigated for attenuation of spinal cord injury after
acute trauma; however, pharmacologically only steroid administration has shown clinical
benefits. This study attempts to characterize local spinal cord histologic response to human
dose equivalent (HDE) intravenous methylprednisolone (MP) administration in a rodent
model of acute spinal cord injury. Design Forty-eight Sprague-Dawley rats were divided
equally into control and experimental groups. Each group was subdivided into eight sets of …
acute trauma; however, pharmacologically only steroid administration has shown clinical
benefits. This study attempts to characterize local spinal cord histologic response to human
dose equivalent (HDE) intravenous methylprednisolone (MP) administration in a rodent
model of acute spinal cord injury. Design Forty-eight Sprague-Dawley rats were divided
equally into control and experimental groups. Each group was subdivided into eight sets of …
Abstract
Objective
Many substances have been investigated for attenuation of spinal cord injury after acute trauma; however, pharmacologically only steroid administration has shown clinical benefits. This study attempts to characterize local spinal cord histologic response to human dose equivalent (HDE) intravenous methylprednisolone (MP) administration in a rodent model of acute spinal cord injury.
Design
Forty-eight Sprague-Dawley rats were divided equally into control and experimental groups. Each group was subdivided into eight sets of three animals each, according to postinjury intervals. Paraplegia after lower thoracic laminectomy was achieved using a standardized weight drop technique.
Lippincott Williams & Wilkins