[HTML][HTML] The C terminus of SUR1 is required for trafficking of KATP channels
N Sharma, A Crane, JP Clement, G Gonzalez… - Journal of Biological …, 1999 - ASBMB
In beta cells from the pancreas, ATP-sensitive potassium channels, or K ATP channels, are
composed of two subunits, SUR1 and K IR 6.2, assembled in a (SUR1/K IR 6.2) 4
stoichiometry. The correct stoichiometry of channels at the cell surface is tightly regulated by
the presence of novel endoplasmic reticulum (ER) retention signals in SUR1 and K IR 6.2;
incompletely assembled K ATP channels fail to exit the ER/cis-Golgi compartments. In
addition to these retrograde signals, we show that the C terminus of SUR1 has an …
composed of two subunits, SUR1 and K IR 6.2, assembled in a (SUR1/K IR 6.2) 4
stoichiometry. The correct stoichiometry of channels at the cell surface is tightly regulated by
the presence of novel endoplasmic reticulum (ER) retention signals in SUR1 and K IR 6.2;
incompletely assembled K ATP channels fail to exit the ER/cis-Golgi compartments. In
addition to these retrograde signals, we show that the C terminus of SUR1 has an …