New use of BCG for recombinant vaccines
CK Stover, VF De La Cruz, TR Fuerst, JE Burlein… - Nature, 1991 - nature.com
Nature, 1991•nature.com
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is
also a useful vaccine vehicle for delivering protective antigens of multiple pathogens.
Extrachromosomal and integrative expression vectors carrying the regulatory sequences for
major BCG heat-shock proteins have been developed to allow expression of foreign
antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and
cellular immune responses to foreign antigens in mice.
also a useful vaccine vehicle for delivering protective antigens of multiple pathogens.
Extrachromosomal and integrative expression vectors carrying the regulatory sequences for
major BCG heat-shock proteins have been developed to allow expression of foreign
antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and
cellular immune responses to foreign antigens in mice.
Abstract
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
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