Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis
VK Sambandamurthy, SC Derrick… - Infection and …, 2005 - Am Soc Microbiol
VK Sambandamurthy, SC Derrick, KV Jalapathy, B Chen, RG Russell, SL Morris…
Infection and immunity, 2005•Am Soc MicrobiolWe report the safety and immunogenicity of a double lysine and pantothenate auxotroph of
Mycobacterium tuberculosis in mice. The Δ lysA Δ panCD mutant is completely attenuated in
immunocompromised SCID and gamma interferon knockout mice yet induces short-term
and long-term protection in immunocompetent and CD4-deficient mice following single-dose
subcutaneous vaccination.
Mycobacterium tuberculosis in mice. The Δ lysA Δ panCD mutant is completely attenuated in
immunocompromised SCID and gamma interferon knockout mice yet induces short-term
and long-term protection in immunocompetent and CD4-deficient mice following single-dose
subcutaneous vaccination.
Abstract
We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.
American Society for Microbiology