Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: transfer to human scalp explants on Prkdcscid mice
A Gilhar, M Landau, B Assy, R Shalaginov… - Archives of …, 2002 - jamanetwork.com
Objective To determine the role of CD4+ and CD8+ T lymphocytes in the pathogenesis of
alopecia areata. Design Relapse of alopecia areata was induced in autologous human
scalp grafts on Prkdc scid mice by injection of activated T lymphocytes derived from lesional
skin. CD4+ and CD8+ T cells were separated by magnetic beads before injection. Setting
University-based dermatology practice. Participants Eleven patients with either alopecia
totalis or severe alopecia areata. Main Outcome Measures Hair regrowth, hair loss, and …
alopecia areata. Design Relapse of alopecia areata was induced in autologous human
scalp grafts on Prkdc scid mice by injection of activated T lymphocytes derived from lesional
skin. CD4+ and CD8+ T cells were separated by magnetic beads before injection. Setting
University-based dermatology practice. Participants Eleven patients with either alopecia
totalis or severe alopecia areata. Main Outcome Measures Hair regrowth, hair loss, and …