[HTML][HTML] Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors
WY Zhang, PM Gaynor, HS Kruth - Journal of Biological Chemistry, 1996 - ASBMB
Human monocyte-derived macrophages can efflux accumulated cholesterol without
exogenously added cholesterol acceptors (Kruth, HS, Skarlatos, SI, Gaynor, PM, and
Gamble, W.(1994) J. Biol. Chem. 269, 24511-24518). Most of the effluxed cholesterol
accumulates in the medium as apolipoprotein E-discoidal lipid particles. In the current study,
we determined whether and to what degree cholesterol efflux from human monocyte-
macrophages depended on apolipoprotein E secretion. Unexpectedly, 2-week-old …
exogenously added cholesterol acceptors (Kruth, HS, Skarlatos, SI, Gaynor, PM, and
Gamble, W.(1994) J. Biol. Chem. 269, 24511-24518). Most of the effluxed cholesterol
accumulates in the medium as apolipoprotein E-discoidal lipid particles. In the current study,
we determined whether and to what degree cholesterol efflux from human monocyte-
macrophages depended on apolipoprotein E secretion. Unexpectedly, 2-week-old …