[HTML][HTML] Inflammation and skin cholesterol in LDLr−/−, apoA-I−/− mice: link between cholesterol homeostasis and self-tolerance?
M Zabalawi, M Bharadwaj, H Horton, M Cline… - Journal of lipid …, 2007 - ASBMB
Diet-fed low density lipoprotein receptor-deficient/apolipoprotein AI-deficient (LDLr−/−, apoA-
I−/−) mice accumulate a 10-fold greater mass of cholesterol in their skin despite a 1.5-to 2-
fold lower plasma cholesterol concentration compared with diet-fed LDLr−/− mice. The
accumulation of cholesterol predominantly in the skin has been shown to occur in a growing
number of other hypercholesterolemic double knockout mouse models sharing deficits in
genes regulating cellular cholesterol homeostasis. Exploring the relationship between …
I−/−) mice accumulate a 10-fold greater mass of cholesterol in their skin despite a 1.5-to 2-
fold lower plasma cholesterol concentration compared with diet-fed LDLr−/− mice. The
accumulation of cholesterol predominantly in the skin has been shown to occur in a growing
number of other hypercholesterolemic double knockout mouse models sharing deficits in
genes regulating cellular cholesterol homeostasis. Exploring the relationship between …