TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell …
BJ Lee, GJ Cho, RB Norgren Jr, MP Junier… - Molecular and Cellular …, 2001 - Elsevier
TTF-1 is a member of the Nkx family of homeodomain genes required for morphogenesis of
the hypothalamus. Whether TTF-1, or other Nkx genes, contributes to regulating
differentiated hypothalamic functions is not known. We now report that postnatal
hypothalamic TTF-1 expression is developmentally regulated and associated with the
neuroendocrine process of female sexual development. Lesions of the hypothalamus that
cause sexual precocity transiently activate neuronal TTF-1 expression near the lesion site. In …
the hypothalamus. Whether TTF-1, or other Nkx genes, contributes to regulating
differentiated hypothalamic functions is not known. We now report that postnatal
hypothalamic TTF-1 expression is developmentally regulated and associated with the
neuroendocrine process of female sexual development. Lesions of the hypothalamus that
cause sexual precocity transiently activate neuronal TTF-1 expression near the lesion site. In …