Regulation of the c-Abl and Bcr–Abl tyrosine kinases
O Hantschel, G Superti-Furga - Nature reviews Molecular cell biology, 2004 - nature.com
Nature reviews Molecular cell biology, 2004•nature.com
The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes.
Its oncogenic counterpart, the Bcr–Abl fusion protein, causes certain human leukaemias.
Recent insights into the structure and regulation of the c-Abl and Bcr–Abl tyrosine kinases
have changed the way we look at these enzymes.
Its oncogenic counterpart, the Bcr–Abl fusion protein, causes certain human leukaemias.
Recent insights into the structure and regulation of the c-Abl and Bcr–Abl tyrosine kinases
have changed the way we look at these enzymes.
Abstract
The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr–Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr–Abl tyrosine kinases have changed the way we look at these enzymes.
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