Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system
Rho GTPases play a fundamental role in a variety of biological processes ranging from the
reorganization of the actin cytoskeleton to the regulation of cell proliferation. The activation
of Rho GTPases is regulated by guanine nucleotide exchange factors (GEFs) belonging to
the Dbl family of proteins. The hallmark of this large family of GEFs is the presence of a
tandem DH-PH module in which a pleckstrin-homology (PH) domain is located at the C-
terminus of a Dbl-homology (DH) domain. Recent studies have demonstrated that SWAP-70 …
reorganization of the actin cytoskeleton to the regulation of cell proliferation. The activation
of Rho GTPases is regulated by guanine nucleotide exchange factors (GEFs) belonging to
the Dbl family of proteins. The hallmark of this large family of GEFs is the presence of a
tandem DH-PH module in which a pleckstrin-homology (PH) domain is located at the C-
terminus of a Dbl-homology (DH) domain. Recent studies have demonstrated that SWAP-70 …