Notch signaling in lymphocyte development and function
EA Robey, JA Bluestone - Current opinion in immunology, 2004 - Elsevier
Current opinion in immunology, 2004•Elsevier
Over the past few years, the crucial role of Notch signaling in multiple stages of T-cell
development has become apparent. Recent studies have helped to define more precisely
the functions and components of the Notch signaling pathway in T-cell development,
including during the T versus B fate decision and in early CD4− CD8− double-negative
thymocytes. In addition, new evidence points to a requirement for Notch2 in the development
of marginal zone B cells. Finally, recent studies have provided our first glimpse into the …
development has become apparent. Recent studies have helped to define more precisely
the functions and components of the Notch signaling pathway in T-cell development,
including during the T versus B fate decision and in early CD4− CD8− double-negative
thymocytes. In addition, new evidence points to a requirement for Notch2 in the development
of marginal zone B cells. Finally, recent studies have provided our first glimpse into the …
Over the past few years, the crucial role of Notch signaling in multiple stages of T-cell development has become apparent. Recent studies have helped to define more precisely the functions and components of the Notch signaling pathway in T-cell development, including during the T versus B fate decision and in early CD4−CD8−double-negative thymocytes. In addition, new evidence points to a requirement for Notch2 in the development of marginal zone B cells. Finally, recent studies have provided our first glimpse into the complex and paradoxical roles of Notch signaling in the activation and differentiation of mature T cells.
Elsevier