[HTML][HTML] The role of conserved amino acid motifs within the integrin β3 cytoplasmic domain in triggering focal adhesion kinase phosphorylation
PD Tahiliani, L Singh, KL Auer… - Journal of Biological …, 1997 - ASBMB
Integrin-mediated adhesion of cells to extracellular matrix proteins triggers a variety of
intracellular signaling pathways including a cascade of tyrosine phosphorylations. In many
cell types, the cytoplasmic focal adhesion tyrosine kinase, FAK, appears to be the initial
protein that becomes tyrosine-phosphorylated in response to adhesion; however, the
molecular mechanisms regulating integrin-triggered FAK phosphorylation are not
understood. Previous studies have shown that the integrin β 1, β 3, and β 5 subunit …
intracellular signaling pathways including a cascade of tyrosine phosphorylations. In many
cell types, the cytoplasmic focal adhesion tyrosine kinase, FAK, appears to be the initial
protein that becomes tyrosine-phosphorylated in response to adhesion; however, the
molecular mechanisms regulating integrin-triggered FAK phosphorylation are not
understood. Previous studies have shown that the integrin β 1, β 3, and β 5 subunit …