[HTML][HTML] Delayed Mammary Tumor Progression in Muc-1 Null Mice (∗)
AP Spicer, GJ Rowse, TK Lidner, SJ Gendler - Journal of Biological …, 1995 - ASBMB
The mucin gene, Muc-1, encodes a high molecular weight integral membrane glycoprotein
that is present on the apical surface of most simple secretory epithelial cells. Muc-1 is highly
expressed and aberrantly glycosylated by most carcinomas and metastatic lesions.
Numerous functions have been proposed for this molecule, including protection of the
epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor
progression. Mice deficient in Muc-1 were generated using homologous recombination in …
that is present on the apical surface of most simple secretory epithelial cells. Muc-1 is highly
expressed and aberrantly glycosylated by most carcinomas and metastatic lesions.
Numerous functions have been proposed for this molecule, including protection of the
epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor
progression. Mice deficient in Muc-1 were generated using homologous recombination in …