Physicochemical basis for formation of renal stones of calcium phosphate origin: calculation of the degree of saturation of urine with respect to brushite
CYC Pak - The Journal of clinical investigation, 1969 - Am Soc Clin Investig
CYC Pak
The Journal of clinical investigation, 1969•Am Soc Clin InvestigBrushite (CaHPO4· 2H2O) was considered to govern the formation of renal calculus of
calcium phosphate origin. The degree of saturation of urine with respect to this phase was
therefore calculated. This value was obtained from the ratio of the activity product of Ca++
and HPO4m (Ksp) before and after incubation of urine with brushite. The errors in the
calculation of Ksp were largely eliminated by this procedure. The urine of patients with
idiopathic hypercalciuria and recurrent calcium-containing renal calculi was supersaturated …
calcium phosphate origin. The degree of saturation of urine with respect to this phase was
therefore calculated. This value was obtained from the ratio of the activity product of Ca++
and HPO4m (Ksp) before and after incubation of urine with brushite. The errors in the
calculation of Ksp were largely eliminated by this procedure. The urine of patients with
idiopathic hypercalciuria and recurrent calcium-containing renal calculi was supersaturated …
Brushite (CaHPO4·2H2O) was considered to govern the formation of renal calculus of calcium phosphate origin. The degree of saturation of urine with respect to this phase was therefore calculated. This value was obtained from the ratio of the activity product of Ca++ and HPO4m (Ksp) before and after incubation of urine with brushite. The errors in the calculation of Ksp were largely eliminated by this procedure.
The urine of patients with idiopathic hypercalciuria and recurrent calcium-containing renal calculi was supersaturated with respect to brushit largely because of the high urinary concentration of Ca++. The urine of normocalciuric subjects was undersaturated except at high urinary pH. This technique of estimating the degree of saturation of urine should allow a quantitative assessment of the various therapeutic regimens recommended for patients with nephrolithiasis.
The Journal of Clinical Investigation