CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice
WA Kuziel, TC Dawson, M Quinones, E Garavito… - Atherosclerosis, 2003 - Elsevier
The accumulation of macrophages and T lymphocytes in vessel walls is a hallmark of
atherogenesis. It has recently been demonstrated in mouse models of atherosclerosis that
full disease potential is dependent on several regulators of leukocyte trafficking, including
the chemokine monocyte chemotactic protein 1 (MCP-1) and the chemokine receptors
CCR2 and CXCR2. A possible role for the chemokine receptor CCR5 in atherogenesis has
been suggested by CCR5 expression on macrophages, T cells, coronary endothelial cells …
atherogenesis. It has recently been demonstrated in mouse models of atherosclerosis that
full disease potential is dependent on several regulators of leukocyte trafficking, including
the chemokine monocyte chemotactic protein 1 (MCP-1) and the chemokine receptors
CCR2 and CXCR2. A possible role for the chemokine receptor CCR5 in atherogenesis has
been suggested by CCR5 expression on macrophages, T cells, coronary endothelial cells …