The brain response to 2-deoxy glucose is blocked by a glial drug
JK Young, JH Baker, MI Montes - Pharmacology Biochemistry and Behavior, 2000 - Elsevier
Two brain regions—the basomedial hypothalamus and area postrema (AP)—react to
changes in circulating glucose levels by altering feeding behavior and the secretion of
pituitary and non-pituitary hormones. The precise identity of cells responding to glucose in
these regions is uncertain. The recent detection of high-capacity glucose transporter
proteins in astrocytes in these areas has suggested that astrocytes may play a role in
glucose sensing by the brain. To test this hypothesis, rats were injected with either saline or …
changes in circulating glucose levels by altering feeding behavior and the secretion of
pituitary and non-pituitary hormones. The precise identity of cells responding to glucose in
these regions is uncertain. The recent detection of high-capacity glucose transporter
proteins in astrocytes in these areas has suggested that astrocytes may play a role in
glucose sensing by the brain. To test this hypothesis, rats were injected with either saline or …