[HTML][HTML] The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif
D Lin, GD Gish, Z Songyang, T Pawson - Journal of biological chemistry, 1999 - ASBMB
Ephrin B proteins function as ligands for B class Eph receptor tyrosine kinases and are
postulated to possess an intrinsic signaling function. The sequence at the carboxyl terminus
of B-type ephrins contains a putative PDZ binding site, providing a possible mechanism
through which transmembrane ephrins might interact with cytoplasmic proteins. To test this
notion, a day 10.5 mouse embryonic expression library was screened with a biotinylated
peptide corresponding to the carboxyl terminus of ephrin B3. Three of the positive cDNAs …
postulated to possess an intrinsic signaling function. The sequence at the carboxyl terminus
of B-type ephrins contains a putative PDZ binding site, providing a possible mechanism
through which transmembrane ephrins might interact with cytoplasmic proteins. To test this
notion, a day 10.5 mouse embryonic expression library was screened with a biotinylated
peptide corresponding to the carboxyl terminus of ephrin B3. Three of the positive cDNAs …