[HTML][HTML] High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib
T Chavakis, S Santoso, KJ Clemetson… - Journal of Biological …, 2003 - ASBMB
Leukocyte-platelet interaction is important in mediating leukocyte adhesion to a thrombus
and leukocyte recruitment to a site of vascular injury. This interaction is mediated at least in
part by the β 2-integrin Mac-1 (CD11b/CD18) and its counter-receptor on platelets,
glycoprotein Ibα (GPIbα). High molecular weight kininogen (HK) was previously shown to
interact with both GPIbα and Mac-1 through its domains 3 and 5, respectively. In this study
we investigated the ability of HK to interfere with the leukocyte-platelet interaction. In a …
and leukocyte recruitment to a site of vascular injury. This interaction is mediated at least in
part by the β 2-integrin Mac-1 (CD11b/CD18) and its counter-receptor on platelets,
glycoprotein Ibα (GPIbα). High molecular weight kininogen (HK) was previously shown to
interact with both GPIbα and Mac-1 through its domains 3 and 5, respectively. In this study
we investigated the ability of HK to interfere with the leukocyte-platelet interaction. In a …