[HTML][HTML] Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet …

N Nanda, M Bao, H Lin, K Clauser, L Komuves… - Journal of Biological …, 2005 - ASBMB
The present study was designed to identify novel membrane proteins that signal during
platelet aggregation. Because one putative mechanism for signaling by a membrane protein
involves phosphorylation, we used oligonucleotide-based microarray analyses and mass
spectrometric proteomics techniques to specifically discover membrane proteins and also
identify those proteins that become phosphorylated on tyrosine, threonine, or serine
residues upon platelet aggregation. Surprisingly, both techniques converged to identify a …