[HTML][HTML] Transcriptional down‐regulation of the platelet ADP receptor P2Y12 and clusterin in patients with systemic lupus erythematosus
L Wang, P Erling, AA Bengtsson, L Truedsson… - Journal of Thrombosis …, 2004 - Elsevier
Cardiovascular complications are common in systemic lupus erythematosus (SLE) and
myocardial infarctions are the leading cause of increased mortality. The ADP receptor P2Y
12 plays a central role in platelet activation and the P2Y 12 blocker clopidogrel reduces the
incidence of cardiovascular events. Clusterin, a complement inhibitory protein suggested to
be involved in the pathogenesis of SLE, has been found recently in a microarray study to be
expressed at very high levels in platelets. Using a new protocol for mRNA quantification in …
myocardial infarctions are the leading cause of increased mortality. The ADP receptor P2Y
12 plays a central role in platelet activation and the P2Y 12 blocker clopidogrel reduces the
incidence of cardiovascular events. Clusterin, a complement inhibitory protein suggested to
be involved in the pathogenesis of SLE, has been found recently in a microarray study to be
expressed at very high levels in platelets. Using a new protocol for mRNA quantification in …