[HTML][HTML] The Platelet Cytoskeleton Stabilizes the Interaction between αⅡbβ3 and Its Ligand and Induces Selective Movements of Ligand-occupied Integrin (∗)
JEB Fox, SJ Shattil, RL Kinlough-Rathbone… - Journal of Biological …, 1996 - ASBMB
Previously, we showed that a subpopulation of the major platelet integrin, α Ⅱb β 3, co-
sediments from detergent lysates with talin and other membrane skeleton proteins. Once α
Ⅱb β 3 has bound adhesive ligand in a platelet aggregate, the detergent-insoluble α Ⅱb β 3
redistributes (along with the detergent-insoluble membrane skeleton proteins and a variety
of signaling molecules) to a fraction that contains cytoplasmic actin filaments. Concomitantly,
certain signaling molecules are activated. The present study shows that, in intact platelets, α …
sediments from detergent lysates with talin and other membrane skeleton proteins. Once α
Ⅱb β 3 has bound adhesive ligand in a platelet aggregate, the detergent-insoluble α Ⅱb β 3
redistributes (along with the detergent-insoluble membrane skeleton proteins and a variety
of signaling molecules) to a fraction that contains cytoplasmic actin filaments. Concomitantly,
certain signaling molecules are activated. The present study shows that, in intact platelets, α …