[HTML][HTML] Protein phosphatase 1 associates with the integrin αIIb subunit and regulates signaling
KV Vijayan, Y Liu, TT Li, PF Bray - Journal of Biological Chemistry, 2004 - ASBMB
Regulation of integrin activation occurs by specific interactions among cytoplasmic proteins
and integrin α and β cytoplasmic tails. We report that the catalytic subunit of protein
phosphatase 1 (PP1c) constitutively associates with the prototypic integrin α IIb β 3 in
platelets and in cell lines overexpressing the integrin. PP1c binds directly to the cytoplasmic
domain of integrin α IIb subunit containing a conserved PP1c binding motif 989 KVGF 992.
Anchored PP1c is inactive, while thrombin-induced platelet aggregation or fibrinogen-α IIb β …
and integrin α and β cytoplasmic tails. We report that the catalytic subunit of protein
phosphatase 1 (PP1c) constitutively associates with the prototypic integrin α IIb β 3 in
platelets and in cell lines overexpressing the integrin. PP1c binds directly to the cytoplasmic
domain of integrin α IIb subunit containing a conserved PP1c binding motif 989 KVGF 992.
Anchored PP1c is inactive, while thrombin-induced platelet aggregation or fibrinogen-α IIb β …