[HTML][HTML] Bidirectional transmembrane modulation of integrin αIIbβ3 conformations
TM Leisner, JD Wencel-Drake, W Wang… - Journal of Biological …, 1999 - ASBMB
Activation of blood platelets by physiological stimuli (eg thrombin, ADP) at sites of vascular
injury induces inside-out signaling, resulting in a conformational change of the prototype
integrin α IIb β 3 from an inactive to an active state competent to bind soluble fibrinogen.
Furthermore, ligand occupancy of α IIb β 3 initiates outside-in signaling and additional
conformational changes of the receptor, leading to the exposure of extracellular neoepitopes
termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal …
injury induces inside-out signaling, resulting in a conformational change of the prototype
integrin α IIb β 3 from an inactive to an active state competent to bind soluble fibrinogen.
Furthermore, ligand occupancy of α IIb β 3 initiates outside-in signaling and additional
conformational changes of the receptor, leading to the exposure of extracellular neoepitopes
termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal …