Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein
NC Andrews, H Erdjument-Bromage, MB Davidson… - Nature, 1993 - nature.com
Nature, 1993•nature.com
Expression of globin genes in developing erythroid cells is controlled by upstream locus
control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor
(NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has
been characterized by complementary DNA cloning as a new basic region–leucine zipper
protein which dimerizes with a ubiquitous partner to form native NF-E2.
control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor
(NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has
been characterized by complementary DNA cloning as a new basic region–leucine zipper
protein which dimerizes with a ubiquitous partner to form native NF-E2.
Abstract
Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region–leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.
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