[HTML][HTML] Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function
H Kojima, A Shinagawa, S Shimizu, H Kanada… - Experimental …, 2001 - Elsevier
OBJECTIVE: Human blood platelets are easily available physiologic target cells for
thrombopoietin (TPO). TPO up-regulates platelet aggregation and α-granule secretion
induced by various agonists. We investigated the role of phosphatidylinositol 3-kinase
(PI3K) and its association with Gab1 in TPO-mediated up-regulation of platelet function.
MATERIALS AND METHODS: PI3K inhibitors (wortmannin and LY294002) and a MAP/ERK-
kinase (MEK) inhibitor (PD98059) were used to investigate the role of these kinases in TPO …
thrombopoietin (TPO). TPO up-regulates platelet aggregation and α-granule secretion
induced by various agonists. We investigated the role of phosphatidylinositol 3-kinase
(PI3K) and its association with Gab1 in TPO-mediated up-regulation of platelet function.
MATERIALS AND METHODS: PI3K inhibitors (wortmannin and LY294002) and a MAP/ERK-
kinase (MEK) inhibitor (PD98059) were used to investigate the role of these kinases in TPO …