[HTML][HTML] Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary …
AE Geddis, NE Fox, K Kaushansky - Journal of Biological Chemistry, 2001 - ASBMB
Thrombopoietin and its receptor (Mpl) support survival and proliferation in megakaryocyte
progenitors and in BaF3 cells engineered to stably express Mpl (BaF3/Mpl). The binding of
thrombopoietin to Mpl activates multiple kinase pathways, including the Jak/STAT,
Ras/Raf/MAPK, and phosphatidylinositol 3-kinase pathways, but it is not clear how these
kinases promote cell cycling. Here, we show that thrombopoietin induces
phosphatidylinositol 3-kinase and that phosphatidylinositol 3-kinase is required for …
progenitors and in BaF3 cells engineered to stably express Mpl (BaF3/Mpl). The binding of
thrombopoietin to Mpl activates multiple kinase pathways, including the Jak/STAT,
Ras/Raf/MAPK, and phosphatidylinositol 3-kinase pathways, but it is not clear how these
kinases promote cell cycling. Here, we show that thrombopoietin induces
phosphatidylinositol 3-kinase and that phosphatidylinositol 3-kinase is required for …