Megakaryocytopoiesis: cellular aspects and regulation
W Vainchenker, N Debili, MA Mouthon… - Critical reviews in …, 1995 - Elsevier
W Vainchenker, N Debili, MA Mouthon, F Wendling
Critical reviews in oncology/hematology, 1995•ElsevierMegakaryocytopoiesis is the cellular system which sustains platelet production. Platelets are
the blood cell which play a major role in hemostasis by their capacity for adhesion to the
endothelium and the sub-endothelium, and by the release of numerous proteins during
activation. Knowledge of the regulation of platelet production remains incomplete despite all
the progress made in the isolation of hematopoietic growth factors and cloning of their
genes. Until recently, this hematopoietic cell lineage was the only one for which a specific …
the blood cell which play a major role in hemostasis by their capacity for adhesion to the
endothelium and the sub-endothelium, and by the release of numerous proteins during
activation. Knowledge of the regulation of platelet production remains incomplete despite all
the progress made in the isolation of hematopoietic growth factors and cloning of their
genes. Until recently, this hematopoietic cell lineage was the only one for which a specific …
Megakaryocytopoiesis is the cellular system which sustains platelet production. Platelets are the blood cell which play a major role in hemostasis by their capacity for adhesion to the endothelium and the sub-endothelium, and by the release of numerous proteins during activation.
Knowledge of the regulation of platelet production remains incomplete despite all the progress made in the isolation of hematopoietic growth factors and cloning of their genes. Until recently, this hematopoietic cell lineage was the only one for which a specific growth factor responsible for homeostasis was not isolated. There are three main reasons for the difficulties in studying megakaryocytopoiesis.
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