[HTML][HTML] Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels
Ca 2+-dependent inactivation (CDI) of L-type Ca 2+ channels plays a critical role in
controlling Ca 2+ entry and downstream signal transduction in excitable cells. Ca 2+-
insensitive forms of calmodulin (CaM) act as dominant negatives to prevent CDI, suggesting
that CaM acts as a resident Ca 2+ sensor. However, it is not known how the Ca 2+ sensor is
constitutively tethered. We have found that the tethering of Ca 2+-insensitive CaM was
localized to the C-terminal tail of α 1C, close to the CDI effector motif, and that it depended …
controlling Ca 2+ entry and downstream signal transduction in excitable cells. Ca 2+-
insensitive forms of calmodulin (CaM) act as dominant negatives to prevent CDI, suggesting
that CaM acts as a resident Ca 2+ sensor. However, it is not known how the Ca 2+ sensor is
constitutively tethered. We have found that the tethering of Ca 2+-insensitive CaM was
localized to the C-terminal tail of α 1C, close to the CDI effector motif, and that it depended …