[HTML][HTML] Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel β3 subunit
M Murakami, H Yamamura, T Suzuki, MG Kang… - Journal of Biological …, 2003 - ASBMB
The β subunits of voltage-dependent calcium channels are known to modify calcium
channel currents through pore-forming α 1 subunits. Of the four β subunits reported to date,
the β3 subunit is highly expressed in smooth muscle cells and is thought to consist of L-type
calcium channels. To determine the role of the β3 subunit in the voltage-dependent calcium
channels of the cardiovascular system in situ, we performed a series of experiments in β3-
null mice. Western blot analysis indicated a significant reduction in expression of the α 1 …
channel currents through pore-forming α 1 subunits. Of the four β subunits reported to date,
the β3 subunit is highly expressed in smooth muscle cells and is thought to consist of L-type
calcium channels. To determine the role of the β3 subunit in the voltage-dependent calcium
channels of the cardiovascular system in situ, we performed a series of experiments in β3-
null mice. Western blot analysis indicated a significant reduction in expression of the α 1 …