Enhanced mutational activity of Vκ gene rearrangements in systemic lupus erythematosus
To determine the differential impact of somatic hypermutation and selective influences on
the light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern
of somatic hypermutations were compared between the productive and nonproductive Vκ
gene repertoire manifested by individual CD19+ B cells in a patient with SLE. The
mutational frequency of nonproductive rearrangements in the SLE patient was significantly
(P< 0.001) increased (3.7× 10− 2) compared to normals (4.8× 10− 3). Similarly, the …
the light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern
of somatic hypermutations were compared between the productive and nonproductive Vκ
gene repertoire manifested by individual CD19+ B cells in a patient with SLE. The
mutational frequency of nonproductive rearrangements in the SLE patient was significantly
(P< 0.001) increased (3.7× 10− 2) compared to normals (4.8× 10− 3). Similarly, the …
Enhanced Mutational Activity and Disturbed Selection of Mutations in VH Gene Rearrangements in a Patient with Systemic Lupus Erythematosus
AM Jacobi, A Hansen, GR Burmester, T Dörner… - …, 2001 - Taylor & Francis
To determine the impact of somatic hypermutation and selective influences on the VH gene
repertoire in SLE, the mutational frequency and pattern of mutations in nonproductively and
productively rearranged VH genes obtained from genomic DNA of individual CD 19+ B cells
were analyzed in a patient with SLE. The mutational frequencies of nonproductive (6.54×
10− 2) as well as of productive (4.38× 10− 2) VH rearrangements were significantly higher in
the SLE patient than in normal controls (3.8× 10− 2 p< 0.001 and 3.3× 10− 2; p< 0.001 …
repertoire in SLE, the mutational frequency and pattern of mutations in nonproductively and
productively rearranged VH genes obtained from genomic DNA of individual CD 19+ B cells
were analyzed in a patient with SLE. The mutational frequencies of nonproductive (6.54×
10− 2) as well as of productive (4.38× 10− 2) VH rearrangements were significantly higher in
the SLE patient than in normal controls (3.8× 10− 2 p< 0.001 and 3.3× 10− 2; p< 0.001 …