[HTML][HTML] Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
M Saxena, S Williams, J Brockdorff, J Gilman… - Journal of Biological …, 1999 - ASBMB
Activation of T lymphocytes to produce cytokines is regulated by the counterbalance of
protein-tyrosine kinases and protein-tyrosine phosphatases, many of which have a high
degree of substrate specificity because of physical association with their targets.
Overexpression of hematopoietic protein-tyrosine phosphatase (HePTP) results in
suppression of T lymphocyte activation as measured by T cell antigen receptor-induced
activation of transcription factors binding to the 5′ promoter of the interleukin-2 gene. Efforts …
protein-tyrosine kinases and protein-tyrosine phosphatases, many of which have a high
degree of substrate specificity because of physical association with their targets.
Overexpression of hematopoietic protein-tyrosine phosphatase (HePTP) results in
suppression of T lymphocyte activation as measured by T cell antigen receptor-induced
activation of transcription factors binding to the 5′ promoter of the interleukin-2 gene. Efforts …