Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia
IP Everall, JD Glass, J McArthur, E Spargo… - Acta …, 1994 - Springer
IP Everall, JD Glass, J McArthur, E Spargo, P Lantos
Acta neuropathologica, 1994•SpringerHuman immune deficiency virus (HIV) disease may be associated, neuropathologically, with
significant neuronal loss and clinically with a severe dementia. However, the significance of
neuronal loss in the development of dementia has not been established. In this study we
have undertaken a stereological determination of the neuronal numerical density and
neuronal volumes in post mortem tissue from the superior frontal and superior temporal gyri
in 32 patients who died of acquired immune deficiency syndrome (AIDS). All were …
significant neuronal loss and clinically with a severe dementia. However, the significance of
neuronal loss in the development of dementia has not been established. In this study we
have undertaken a stereological determination of the neuronal numerical density and
neuronal volumes in post mortem tissue from the superior frontal and superior temporal gyri
in 32 patients who died of acquired immune deficiency syndrome (AIDS). All were …
Abstract
Human immune deficiency virus (HIV) disease may be associated, neuropathologically, with significant neuronal loss and clinically with a severe dementia. However, the significance of neuronal loss in the development of dementia has not been established. In this study we have undertaken a stereological determination of the neuronal numerical density and neuronal volumes in post mortem tissue from the superior frontal and superior temporal gyri in 32 patients who died of acquired immune deficiency syndrome (AIDS). All were prospectively clinically characterized, with dementia identified or excluded, and antiretroviral medication documented. This study combines morphometric techniques with prospective clinical assessment of dementia. As previously demonstrated, all patients dying with AIDS showed neuronal loss, but this was not related to the presence of HIV-associated dementia.
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