[HTML][HTML] Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes
VT Nguyen, J Arredondo, AI Chernyavsky… - Journal of Biological …, 2004 - ASBMB
Pemphigus vulgaris (PV) is a life-threatening autoimmune disease of skin adhesion
associated with IgG autoantibodies against keratinocytes (KC). Treatment of PV with
systemic corticosteroids is life-saving, but the mechanism of the therapeutic action has not
been fully understood. We have developed an animal model that demonstrates that
methylprednisolone (MP) can block PV IgG-induced acantholysis, decreasing the extent of
keratinocyte detachment in the epidermis of 3–5-day-old nude mice from 77.5±0.6 to …
associated with IgG autoantibodies against keratinocytes (KC). Treatment of PV with
systemic corticosteroids is life-saving, but the mechanism of the therapeutic action has not
been fully understood. We have developed an animal model that demonstrates that
methylprednisolone (MP) can block PV IgG-induced acantholysis, decreasing the extent of
keratinocyte detachment in the epidermis of 3–5-day-old nude mice from 77.5±0.6 to …