[HTML][HTML] Differential regulation of the two neuronal nitric-oxide synthase gene promoters by the Oct-2 transcription factor

Z Deans, SJ Dawson, J Xie, AP Young… - Journal of Biological …, 1996 - ASBMB
The Oct-2 transcription factor has been shown previously to repress both the cellular
tyrosine hydroxylase and the herpes simplex virus immediate-early genes in neuronal cells.
Here we identify the gene encoding the neuronal nitric-oxide synthase (nNOS) as the first
example of a gene activated in neuronal cells by Oct-2. The levels of the nNOS mRNA and
protein are greatly reduced in neuronal cell lines in which Oct-2 levels have been reduced
by an antisense method, although these cells have enhanced levels of tyrosine hydroxylase …