Neuronal nitric oxide (NO) synthase, localized to human chromosome 12, uniquely
participates in diverse biologic processes; neurotransmission, the regulation of body fluid
homeostasis, neuroendocrine physiology, control of smooth muscle motility, sexual function,
and myocyte/myoblast biology, among others. Restriction enzyme mapping, subcloning, and
DNA sequence analysis of bacteriophage-and yeast artificial chromosome-derived human
genomic DNA indicated that the mRNA for neuronal NO synthase is dispersed over a …