[HTML][HTML] Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins
C Moreau, PF Cartron, A Hunt, K Meflah… - Journal of Biological …, 2003 - ASBMB
The pro-apoptotic" BH3 domain-only" proteins of the Bcl-2 family (eg Bid and Bad) transduce
multiple death signals to the mitochondrion. They interact with the anti-apoptotic Bcl-2 family
members and induce apoptosis by a mechanism that requires the presence of at least one of
the multidomain pro-apoptotic proteins Bax or Bak. Although the BH3 domain of Bid can
promote the pro-apoptotic assembly and function of Bax/Bak by itself, other BH3 domains do
not function as such. The latter point raises the question of whether, and how, these BH3 …
multiple death signals to the mitochondrion. They interact with the anti-apoptotic Bcl-2 family
members and induce apoptosis by a mechanism that requires the presence of at least one of
the multidomain pro-apoptotic proteins Bax or Bak. Although the BH3 domain of Bid can
promote the pro-apoptotic assembly and function of Bax/Bak by itself, other BH3 domains do
not function as such. The latter point raises the question of whether, and how, these BH3 …