Involvement of 5-HT1A receptors in behavioural effects of the cannabinoid receptor agonist CP 55,940 in male rats
EM Marco, L Perez-Alvarez, E Borcel… - Behavioural …, 2004 - journals.lww.com
We have studied the possible interaction between the cannabinoid receptor agonist CP
55,940 (1 and 50 μg/kg) and the 5-HT 1A receptor antagonist WAY 100635 (1 mg/kg) in the
modulation of plus-maze and holeboard activity in Wistar adult male rats. In the plus-maze,
the higher dose of CP 55,940 induced an anxiogenic-like effect, whereas the lower dose
induced anxiolytic-like responses. The 5-HT 1A antagonist, which was silent in this test,
attenuated the anxiogenic, but not the anxiolytic, effect of CP 55,940. In the holeboard, the …
55,940 (1 and 50 μg/kg) and the 5-HT 1A receptor antagonist WAY 100635 (1 mg/kg) in the
modulation of plus-maze and holeboard activity in Wistar adult male rats. In the plus-maze,
the higher dose of CP 55,940 induced an anxiogenic-like effect, whereas the lower dose
induced anxiolytic-like responses. The 5-HT 1A antagonist, which was silent in this test,
attenuated the anxiogenic, but not the anxiolytic, effect of CP 55,940. In the holeboard, the …