Progressive development of a Th1-type hepatic cytokine profile in rats with experimental cholangitis
K Tjandra, KA Sharkey, MG Swain - Hepatology, 2000 - journals.lww.com
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are presumed
autoimmune chronic cholestatic liver diseases characterized by cholangitis and progressive
loss of bile ducts. Cytokines have been postulated to be involved in the progression of these
diseases, but their role is poorly defined. Our objectives were to characterize a rat model of
cholangitis and to determine Type 1/Type 2 (Th1/Th2) cytokine profile shifts in this model.
Cholangitis was induced in Sprague-Dawley rats (200 to 225 g) by low-dose oral …
autoimmune chronic cholestatic liver diseases characterized by cholangitis and progressive
loss of bile ducts. Cytokines have been postulated to be involved in the progression of these
diseases, but their role is poorly defined. Our objectives were to characterize a rat model of
cholangitis and to determine Type 1/Type 2 (Th1/Th2) cytokine profile shifts in this model.
Cholangitis was induced in Sprague-Dawley rats (200 to 225 g) by low-dose oral …