[HTML][HTML] Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor
MS Ali, PP Sayeski, LB Dirksen, DJ Hayzer… - Journal of Biological …, 1997 - ASBMB
Angiotensin II is the effector molecule of the renin-angiotensin system. Virtually all of its
biochemical actions are mediated through a single class of cell-surface receptors called AT
1. These receptors contain the structural features of the seven-transmembrane, G-protein-
coupled receptor superfamily. Angiotensin II, acting through the AT 1 receptor, also
stimulates the Jak/STAT pathway by inducing ligand-dependent Jak2 tyrosine
phosphorylation and activation. Here, we show that a glutathione S-transferase fusion …
biochemical actions are mediated through a single class of cell-surface receptors called AT
1. These receptors contain the structural features of the seven-transmembrane, G-protein-
coupled receptor superfamily. Angiotensin II, acting through the AT 1 receptor, also
stimulates the Jak/STAT pathway by inducing ligand-dependent Jak2 tyrosine
phosphorylation and activation. Here, we show that a glutathione S-transferase fusion …