Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography: a meta-analysis

E Masci, A Mariani, S Curioni, PA Testoni - Endoscopy, 2003 - thieme-connect.com
E Masci, A Mariani, S Curioni, PA Testoni
Endoscopy, 2003thieme-connect.com
Results: When patient-related risk factors were analysed, the relative risk for suspected
sphincter of Oddi dysfunction was 4.09 (95% CI 3.37 to 4.96; P< 0.001); for female gender,
2.23 (95% CI 1.75 to 2.84, P< 0.001); and for previous pancreatitis, 2.46 (95% CI 1.93 to
3.12, P< 0.001). Two endoscopy-related factors were confirmed: for precut sphincterotomy
the relative risk was 2.71 (95% CI 2.02 to 3.63, P< 0.001); for pancreatic injection the relative
risk was 2.2 (95% CI 1.6 to 3.01, P< 0.001). Conclusions: This meta-analysis provides a …
Results: When patient-related risk factors were analysed, the relative risk for suspected sphincter of Oddi dysfunction was 4.09 (95% CI 3.37 to 4.96; P< 0.001); for female gender, 2.23 (95% CI 1.75 to 2.84, P< 0.001); and for previous pancreatitis, 2.46 (95% CI 1.93 to 3.12, P< 0.001). Two endoscopy-related factors were confirmed: for precut sphincterotomy the relative risk was 2.71 (95% CI 2.02 to 3.63, P< 0.001); for pancreatic injection the relative risk was 2.2 (95% CI 1.6 to 3.01, P< 0.001).
Conclusions: This meta-analysis provides a clear basis for planning pharmacological studies or studies of new endoscopic techniques in patients at high risk of developing post-ERCP pancreatitis. Knowing which patients are most at risk may also make it easier to decide who should be considered unsuitable for same-day discharge.
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