[HTML][HTML] The phosphorylation site located in the A region of retinoic X receptor α is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA …
J Bastien, S Adam-Stitah, JL Plassat… - Journal of Biological …, 2002 - ASBMB
Mouse F9 embryocarcinoma cells constitute a well established cell autonomous model
system for investigating retinoic acid (RA) signaling in vitro. RA induces the differentiation of
F9 cells grown as monolayers into endodermal-like cells and decreases their rate of
proliferation. Knock-out of the retinoic X receptor α (RXRα) gene abolishes endodermal
differentiation and the induction of several endogenous RA-responsive genes. RXRα null
cells are also drastically impaired in their antiproliferative response to RA. The role of the …
system for investigating retinoic acid (RA) signaling in vitro. RA induces the differentiation of
F9 cells grown as monolayers into endodermal-like cells and decreases their rate of
proliferation. Knock-out of the retinoic X receptor α (RXRα) gene abolishes endodermal
differentiation and the induction of several endogenous RA-responsive genes. RXRα null
cells are also drastically impaired in their antiproliferative response to RA. The role of the …